MovDisordV3, Main, Exploration, bibRecord, 004761

Long‐Term follow‐up on restless legs syndrome patients treated with opioids

Identifieur interne : 004761 ( Main/Exploration ); précédent : 004760; suivant : 004762

Long‐Term follow‐up on restless legs syndrome patients treated with opioids

Auteurs : Arthur S. Walters [États-Unis] ; Juliane Winkelmann [Allemagne] ; Claudia Trenkwalder [Allemagne] ; June M. Fry [États-Unis] ; Vandana Kataria [États-Unis] ; Mary Wagner [États-Unis] ; Rakesh Sharma [États-Unis] ; Wayne Hening [États-Unis] ; Liren Li [États-Unis]

Source :

Movement Disorders [ 0885-3185 ] ; 2001-11.

RBID : ISTEX:1B01CD1E85732FB9D3185AA1996CF7F5578849F4

Descripteurs français

Pascal (Inist)
- Chimiothérapie, Electrodiagnostic, Etude longitudinale, Evolution, Homme, Impatience membre inférieur syndrome, Long terme, Opiacés, Polygraphie, Sommeil.
Wicri :
- geographic : Allemagne, États-Unis.
- topic : Homme.

English descriptors

KwdEn :
- Aged, Aged, 80 and over, Chemotherapy, Drug Therapy, Combination, Electrodiagnosis, Evolution, Female, Follow up study, Follow-Up Studies, Germany, Human, Humans, Long term, Male, Middle Aged, Narcotics (adverse effects), Narcotics (therapeutic use), Opiates, Opioid-Related Disorders, Opioids, Patient Compliance, Polygraphy, Polysomnography, Restless Legs Syndrome (drug therapy), Restless legs syndrome, Retrospective Studies, Sleep, Sleep Apnea Syndromes (chemically induced), Treatment Outcome, United States, opiates, periodic limb movements in sleep, restless legs syndrome, sleep, sleep apnea.
MESH :
- chemical , adverse effects : Narcotics.
- chemical , therapeutic use : Narcotics.
- geographic : Germany, United States.
- chemically induced : Sleep Apnea Syndromes.
- drug therapy : Restless Legs Syndrome.
- Aged, Aged, 80 and over, Drug Therapy, Combination, Female, Follow-Up Studies, Humans, Male, Middle Aged, Opioid-Related Disorders, Patient Compliance, Polysomnography, Retrospective Studies, Treatment Outcome.

Abstract

The medical records of 493 patients with restless legs syndrome (RLS) from three major centers were studied to determine the number and outcome of patients who had been treated with opioids as a monotherapy. At one time or another 113 patients (51 men, 62 women; age range, 37–88 years) had been on opioid therapy either alone (36 patients) or with opioids added secondarily to other medications used to treat RLS (77 patients). Twenty‐three of the 36 opioid monotherapy patients had failed dopaminergic and other therapeutic agents prior to the initiation of opioid monotherapy. Twenty of the 36 opioid monotherapy patients continue on monotherapy for an average of 5 years 11 months (range, 1–23 years), despite their knowledge of the availability of other therapies. Of the 16 patients who discontinued opioids as a sole therapy, the medication was discontinued in only one case because of problems related to addiction and tolerance. Polysomnography on seven patients performed after an average of 7 years 1 month of opioid monotherapy (range, 1–15 years) showed a tendency toward an improvement in all leg parameters and associated arousals (decrease in PLMS index, PLMS arousal index, and PLM while awake index) as well as all sleep parameters (increase in stages 3 and 4 and REM sleep, total sleep time, sleep efficiency, and decrease in sleep latency). Two of these seven patients developed sleep apnea and a third patient had worsening of preexisting apnea. Opioids seem to have long‐term effectiveness in the treatment of RLS and PLMS, but patients on long‐term opioid therapy should be clinically or polysomnographically monitored periodically for the development of sleep apnea. © 2001 Movement Disorder Society.

Url:

https://api.istex.fr/document/1B01CD1E85732FB9D3185AA1996CF7F5578849F4/fulltext/pdf

DOI: 10.1002/mds.1214

Affiliations:

Le document en format XML

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<term>Aged, 80 and over</term>
<term>Chemotherapy</term>
<term>Drug Therapy, Combination</term>
<term>Electrodiagnosis</term>
<term>Evolution</term>
<term>Female</term>
<term>Follow up study</term>
<term>Follow-Up Studies</term>
<term>Germany</term>
<term>Human</term>
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<front><div type="abstract" xml:lang="en">The medical records of 493 patients with restless legs syndrome (RLS) from three major centers were studied to determine the number and outcome of patients who had been treated with opioids as a monotherapy. At one time or another 113 patients (51 men, 62 women; age range, 37–88 years) had been on opioid therapy either alone (36 patients) or with opioids added secondarily to other medications used to treat RLS (77 patients). Twenty‐three of the 36 opioid monotherapy patients had failed dopaminergic and other therapeutic agents prior to the initiation of opioid monotherapy. Twenty of the 36 opioid monotherapy patients continue on monotherapy for an average of 5 years 11 months (range, 1–23 years), despite their knowledge of the availability of other therapies. Of the 16 patients who discontinued opioids as a sole therapy, the medication was discontinued in only one case because of problems related to addiction and tolerance. Polysomnography on seven patients performed after an average of 7 years 1 month of opioid monotherapy (range, 1–15 years) showed a tendency toward an improvement in all leg parameters and associated arousals (decrease in PLMS index, PLMS arousal index, and PLM while awake index) as well as all sleep parameters (increase in stages 3 and 4 and REM sleep, total sleep time, sleep efficiency, and decrease in sleep latency). Two of these seven patients developed sleep apnea and a third patient had worsening of preexisting apnea. Opioids seem to have long‐term effectiveness in the treatment of RLS and PLMS, but patients on long‐term opioid therapy should be clinically or polysomnographically monitored periodically for the development of sleep apnea. © 2001 Movement Disorder Society.</div>
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Movement Disorders (revue)

Long‐Term follow‐up on restless legs syndrome patients treated with opioids

Long‐Term follow‐up on restless legs syndrome patients treated with opioids

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

	Movement Disorders (revue)
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.